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Structural biochemistry of DNA repair - from molecular mechanisms to targeted cancer therapy

Mercredi 27 novembre 2013 14:00 - Duree : 1 heure
Lieu : Auditorium, Central Building, ESRF - 6 Rue Jules Horowitz - Grenoble

Orateur : Meike STELTER (CNRS Grenoble, France)

DNA repair is a fundamental and vital cellular process. The genome is constantly subjected to conditions that induce DNA damage, including radiation and other environmental or endogenous factors, causing tens of thousands of DNA lesions per day in each cell, which, if left unrepaired, lead to various deleterious biological effects. Defects in DNA repair pathways are related with a number of human diseases and susceptibilities to cancer. On the other hand, because most commonly used cancer therapies cause cell death by damaging DNA, and because the damage produced by the therapeutic agents can often be repaired by DNA repair proteins, paradoxically, they also significantly reduce the efficiency of chemo- or radiotherapy of human cancers. In my talk I will present our work on Deinococcus radiodurans Uvr proteins involved in the nucleotide excision DNA repair pathway, analysing the mechanisms of damage recognition by the UvrA proteins and the structure and mechanism of the DNA helicase UvrD.

The second part of my presentation will concern the human endonuclease III, hNTH1, participating in the base excision DNA repair pathway and responsible for recognizing and removing certain types of oxidized pyrimidines. The complex of hNTH1 with the multifunctional protein YB1 was associated with chemotherapeutic resistance of human cancers, which makes the enzymatic activity of hNTH1 and its interaction with YB1 promising targets for the treatment of drug resistant tumors. I will present my current results on the functional analysis of hNTH1 and its complex with YB1.

Contact : claudine.romero@esrf.fr

Discipline évènement : (Physique)
Entité organisatrice : (ESRF)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire ESRF)
Site de l'évènement : Polygone scientifique

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