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The heat-transfer method HTM : a new concept for biosensors

Mardi 10 février 2015 17:00 - Duree : 2 heures
Lieu : Salle de visio-conférence du Bâtiment André Rassat |RdC | 470, rue de la Chimie | Campus Saint Martin d’ Hères

Orateur : Prof. Patrick WAGNER (K.U.Leuven, Belgium)

In this contribution we will report on the heat-transfer method (HTM), which was discovered in 2012 by serendipity during studies on the thermally induced denaturation of DNA brushes immobilized on synthetic diamond electrodes. By heating the chip from the backside, the heat-transfer resistance Rth of the solid-liquid interface shows an unexpected jump upon the conformational change from rigid ds-DNA to flexible ss-DNA. This way, the DNA-melting temperature can be identified thermometrically and this straightforward method is sufficiently sensitive to detect single-nucleotide polymorphisms. Interestingly enough, the heat-transfer method can also serve as a readout principle in a variety of other bioanalytical challenges including i) the identification of cancer cells by whole-cell receptors, ii) the detection of neurotransmitters, and iii) the monitoring of phase transitions in lipid vesicles. Although the heat-transfer effect is theoretically not yet understood, it appears to be related to a softening of molecular vibrations at the interphase between the sensor chip and the aqueous phase.

Prof. Patrick Wagner Patrick Wagner received his Ph.D. in physics in 1994 at the Technical University Darmstadt (Germany) and joined the Laboratory for Solid State Physics at the Catholic University Leuven (Belgium) in 1995 where he focused on the magneto-transport properties of mixed-valency magnetic oxides. In 2001 he was appointed as a professor of experimental physics at Hasselt University where he established a new research group on biosensors. In 2014 he moved back to KU Leuven as a full professor for bio- and soft-matter physics with a special focus on bio-functional surfaces. Patrick Wagner received several scientific distinctions including a Marie-Curie fellowship of the European Union (1996 – 1998) and a Methusalem grant of the Flemish Government (2008 – 2014).

More info : https://master-nanosciences.ujf-grenoble.fr/sites/default/files/Formation/brochure_capita_selecta2014-2015.pdf

Acces map on : http://tech.neel.cnrs.fr/rtrananoscience/files/web/Plan_salledeconference_Rassat_SMH.pdf

Discipline évènement : (Biologie / Chimie) - Discipline évènement : (Physique)
Entité organisatrice : (Master Erasmus Mundus Nano)
Nature évènement : (Séminaire)
Evènement répétitif : (Capita Selecta Lectures Series)
Site de l'évènement : Domaine Universitaire de St Martin d’Hères

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