Geometric Control of Tissue Growth and Organisation
Lundi 16 mars 2015 14:00
- Duree : 1 heure
Lieu : Conference room - LIPhy - Bât E - 140 Avenue de la Physique - St Martin d’Hères. Accès par interphone, appeler le secrétariat
Orateur : Cécile BIDAN (LIPHY-MOTIV, Université Joseph Fourier Grenoble & CNRS)
As in morphogenesis, wound healing and bone remodelling, the various tissues of our body are continuously modelled, remodelled and repaired by the cells. Even if these biological processes are encoded in genetics, the cells also adapt to the physical cues of their surroundings. For example, by determining the boundary conditions for the mechanical environment, geometry has been shown to influence biological mechanisms at the sub-cellular, cellular and multi-cellular levels. Here we aim at understanding how the geometry of a substrate influences the deposition and organisation of tissue.
Osteoblasts were cultured to grow bone tissue in three-dimensional hydroxyapatite scaffolds in-vitro. In parallel, the hypothesis that geometry locally influences tissue deposition on a surface was implemented into a computational model of curvature-driven growth. A geometrical interpretation based on elongated contractile cells was proposed to link this model to the organization of the cells observed in the tissue. Finally, the structural investigations were extended to the extracellular matrix to further clarify the mechanisms involved in tissue patterning and organization.
Contact : aurelie.dupont@ujf-grenoble.fr
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