Precision Drug Delivery With Ultrasound And Microbubbles : Mechanisms, Applications and Progress to Clinics
Lundi 23 mars 2015 14:00
- Duree : 1 heure
Lieu : Conference room - LIPhy - Bât E - 140 Avenue de la Physique - St Martin d’Hères. Accès par interphone, appeler le secrétariat
Orateur : Ayache BOUAKAZ (Inserm U930, Université François Rabelais, Tours, France)
Targeted drug delivery (delivery of a drug to a spatially localized site in the human body) is one of the most ambitious goals of modern therapy. The strict localization of the pharmacological activity of a drug to the site of pathology would result in a significant reduction in systemic drug toxicity. In recent years, new promising possibilities for targeted drug delivery have been discovered based on the combination of ultrasound (US) and microbubbles. Sonoporation, which consists of the interaction of US waves and gas microbubbles induces a transient permeabilization of the cell membrane allowing for the uptake of drugs or DNA.
Today, the mechanisms involved in the sonoporation process and the cell membrane permeabilization remain poorly identified. Although no consensus has been reached, several scenarios have been hypothesized, including the formation of pores, further stimulation of endocytotic pathways and occurrence of membrane wounds. Elucidating the mechanisms responsible for delivery of compounds to the cells and the kinetics of permeabilization are essential in order to improve and control this therapeutic strategy. This talk will focus on the current knowledge of the mechanisms of sonoporation and drug delivery using US and microbubbles. We will also discuss the current therapeutic applications of microbubbles and future progress and potential translational use into clinics.
Contact : philippe.marmottant@ujf-grenoble.fr
Discipline évènement : (Physique)
Entité organisatrice : (LIPhy)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire Mat. Molle/grise)
Site de l'évènement : Domaine Universitaire de St Martin d’Hères
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