Voltage Imaging – A Path Towards The Measurement Of The Input-Output Transform Function Of A Neuron
Lundi 18 mai 2015 14:00
- Duree : 1 heure
Lieu : Conference room - LIPhy - Bât E - 140 Avenue de la Physique - St Martin d’Hères. Accès par interphone, appeler le secrétariat
Orateur : Marko POPOVIC (Netherlands Institute for Neuroscience, Amsterdam)
I have advanced the voltage imaging technique and used it in combination with classic electrode-based electrophysiology to study emergence and propagation of electrical events in both input and output structures within single mammalian neurons at unprecedented temporal resolution. I have measured the exact location and size of the action potential initiation site (axon initial segment) where the output is generated. I have observed directly how this structure changes in development and recorded in high spatio-temporal resolution the saltatory nature of action potential propagation in adult mammalian neurons. On the input side of a neuron, I made some of the first direct measurements of the electrical properties of the dendritic spines. A notable finding of these studies is that spine heads are not electrically isolated from the primary dendrites. Spine heads in layer 5 neocortical neurons rather act as a separate biochemical (but not electrical) sub-cellular compartment.
Contact : marco.canepari@ujf-grenoble.fr
Discipline évènement : (Physique)
Entité organisatrice : (LIPhy)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire Mat. Molle/grise)
Site de l'évènement : Domaine Universitaire de St Martin d’Hères
Prévenir un ami par email
Télécharger dans mon agenda