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Cell-Matrix Feedback from the Single Cell to the Tissue Scale

Lundi 29 juin 2015 14:00 - Duree : 1 heure
Lieu : Conference room - LIPhy - Bât E - 140 Avenue de la Physique - St Martin d’Hères. Accès par interphone, appeler le secrétariat

Orateur : Philip KOLLMANNSBERGER (ETH, Laboratory of Applied Mechanobiology, Zurich, Switzerland)

The continuous interaction of cells with each other through the extracellular matrix (ECM) during growth and remodeling defines a feedback loop that is important for controlling tissue self-organization. I will present various techniques to quantify the mechanobiology of cell-matrix interactions from the single cell to the tissue scale. Using ECM-coated magnetic microbeads, the response of the cell-matrix interface to large forces was probed and a universal relationship between the contractility and the nonlinear viscoelasticity of the cell was found. In a multicellular context, the balance of cell contractility and substrate geometry was found to determine both the conformation of the deposited ECM and the proliferation patterns in growing microtissues. This implies that scaffold geometry can be specifically engineered to pattern active stresses in order to direct cell behavior and ECM organization towards a desired functional outcome. These studies were complemented by imaging and quantification of cell networks and ECM organization in healthy and diseased ex vivo tissue, and by computational modeling of the complex feedback systems that link cell-level behavior to tissue-level response. Together, these studies result in a more quantitative understanding of cell-matrix mechanobiology and thus help to improve regenerative therapies for contractile force-bearing tissues.

Contact : cecile.bidan@ujf-grenoble.fr

Discipline évènement : (Physique)
Entité organisatrice : (LIPhy)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire Mat. Molle/grise)
Site de l'évènement : Domaine Universitaire de St Martin d’Hères

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