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Anesthetic drug interaction with the phospholipid membrane

Vendredi 3 juin 2016 10:00 - Duree : 1 heure
Lieu : ILL 4, Seminar Room, 71 avenue des Martyrs - Grenoble

Orateur : Petru NIGA (Technical Research Institute of Sweden)

General anesthesia is an induced physiological state of unconsciousness when the patient becomes amnesic, totally relaxed and loses the response to pain. Even though there is more than 150 years since general anesthesia was introduced in medical surgery practice, the molecular mechanism by which drugs can produce this state is still under debate. One of the main reasons is that the chemical diversity of the existing general anesthetics is significant and includes a range of compounds administrated by inhalation (e.g. diethyl ether, nitrous oxide, xenon, enflurane and halothane) or intravenously (e.g. thiopental, ketamine, etomidate and propofol).

To gain more understanding of the interaction between anaesthetics drugs with phospholipid membranes, we focused our work on one particular drug molecule, propofol, which is predominantly hydrophobic but contains a hydrophilic OH-group located in the middle of the molecule. Propofol is probably most well-known for inducing general anaesthesia ; however it has antioxidant, anxiolytic, analgesic, immunomodulatory and anticancer effects.

We have used Langmuir through together with the surface specific laser technique vibrational sum frequency spectroscopy (VSF) to investigate propofol-induced changes in the molecular order in both the hydrophilic head group region and the hydrophobic chain region of three saturated phosphatidylcholines of different chain lengths. In addition, the propofol itself has been targeted, as also the water molecules hydrating the lipids and the propofol. The studies have been performed at 25 mNm-1, to mimic a biological membrane, as well as at 5 mNm-1, in order to gain understanding of how the surface pressure affects the ability of propofol to interact with phospholipids.

Contact : tellier@ill.fr

Discipline évènement : (Physique)
Entité organisatrice : (ILL)
Nature évènement : (Séminaire)
Evènement répétitif : (General ILL Seminar - College 9)
Site de l'évènement : Polygone scientifique

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