Blood flow in microfluidic architectures : collective behaviors of deformable particles in confined flow
Mercredi 11 mai 2016 14:30
- Duree : 2 heures
Lieu : Conference room - LIPhy - Bât E - 140 Avenue de la Physique - St Martin d’Hères. Accès par interphone, appeler le secrétariat
Orateur : Soutenance de Thèse de Zaiyi SHEN
Blood flow in the microcirculation is essential for delivery of nutrients to tissues and organs. To better understand the properties of red blood cell (RBC) flow in microcirculation, this thesis focuses on the collective behaviors of RBCs in confined shear flow and in networks. I) We numerically study the link between the spatiotemporal organization of the RBC suspension and rheology by using an immersed boundary-lattice Boltzmann method. We show that in a confined blood suspension, RBCs spontaneously organize in a crystalline-like structure under the sole effect of hydrodynamic interaction. II) The partition of RBCs at the level of bifurcations is addressed in our computer simulations and in vitro experiments. In the case of extreme hemodilution, our results exhibit a new phenomenon in opposition to the known Zweifach-Fung effect. Finally, the RBC transit is investigated through simulations of a large number of RBCs flowing in a network pattern structured as a honeycomb.
The defence will be in english
Contact : delphine.debarre@univ-grenoble-alpes.fr
Discipline évènement : (Physique)
Entité organisatrice : (LIPhy)
Nature évènement : (Soutenance de thèse)
Site de l'évènement : Domaine Universitaire de St Martin d’Hères
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