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Radiobiology data for improving BNCT treatment planning

Mardi 28 juin 2016 14:00 - Duree : 1 heure
Lieu : Seminar Room 7/8 - ILL 1, 71 avenue des Martyrs, Grenoble

Orateur : María PEDROSA (Departamento de Física Atómica, Molecular y Nuclear, Universidad de Granada)

Boron Neutron Capture Therapy (BNCT) is an experimental form of cancer therapy which has shown encouraging clinical results in the last years. It is based on the irradiation with low energy neutrons of a tumour previously doped with a boron compound. For each neutron captured by 10B, two energetic light ions are emitted but with a very short range so that mainly the cells where the boron has been absorbed are damaged by this reaction. Light ions have a much higher biological effectiveness (LET) than radiation used in conventional cancer radiotherapy. With BNCT it is possible to treat tumours resistant to conventional radiotherapy (low LET) and tumours intermingled with healthy tissue.

This technique has recently been applied in clinical trials in several countries around the world, especially in Japan, Finland, Argentina and Italy, for cases of very poor prognosis as brain tumours (glioblastoma multiforme) or recurrent head and neck cancers. It has also shown good results in palliative care.

In BNCT treatment planning, the effective (biological) weighted dose must be evaluated, at least approximately, in order to compare the values to the dose delivered in conventional radiotherapy treatments. This is a key problem because the weighted dose in the healthy tissue is the usual constraint in treatment planning. Several assumptions and approximations are used in the currently used weighting factors.

We have proposed a new formalism for a better estimate of the effective dose as well as an improved comparison to conventional radiotherapy, in order to anticipate the effects of BNCT in the tissue in a more accurate way. The new hypothesis needs to be confirmed by radiobiology experiments with cells.

Moreover, since the neutron radiobiology data of interest for BNCT are generally scarce, more data are required by the neutron irradiation of cells culture in different conditions. The results of this research will be directly applicable to future treatments with BNCT (bench-to-bedside).

Contact : tellier@ill.fr

Discipline évènement : (Biologie / Chimie) - Discipline évènement : (Physique)
Entité organisatrice : (ILL)
Nature évènement : (Séminaire)
Evènement répétitif : (General ILL Seminar - College 3)
Site de l'évènement : Polygone scientifique

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