Mechanotransduction from Cell Surface to Nucleus : Roles of E-Cadherin in Catenin Signaling
Lundi 27 juin 2016 14:00
- Duree : 1 heure
Lieu : Conference room - LIPhy - Bât E - 140 Avenue de la Physique - St Martin d’Hères. Accès par interphone, appeler le secrétariat
Orateur : Nicolas BORGHI (Institut Jacques Monod, Paris)
In multicellular organisms, cells generate and undergo mechanical forces that propagate through tissues. These forces may shape cells, tissues and organs, and also regulate genetic programs. We seek to elucidate the intimate mechanisms of the macromolecular complexes that transmit and transduce these mechanical cues within and between cells, and the cell functions affected by these cues.
We are currently interested in the intercellular adhesion complex comprising E-cadherins and catenins in epithelial cells. E-cadherins are transmembrane proteins that form intercellular bonds between adjacent cells and recruit cytoskeletal linkers catenins in the cytoplasm. Remarkably, catenins are also regulators of gene transcription when in the nucleus, and this activity may be triggered by biochemical as well as mechanical cues during major morphogenetic processes and disease. The roles of E-cadherins in the mechanical induction of catenin-dependent genes is, however, poorly understood.
I will present our recent advances in addressing this question, using genetically encoded biosensors and fluorescence microscopy.
Contact : aurelie.dupont@univ-grenoble-alpes.fr
Discipline évènement : (Physique)
Entité organisatrice : (LIPhy)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire Mat. Molle/grise)
Site de l'évènement : Domaine Universitaire de St Martin d’Hères
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