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The Vocal-Fold Tissue : 3D Fibrous Architecture and Biomechanics

Lundi 8 janvier 14:00 - Duree : 1 heure
Lieu : Conference room - LIPhy - Bât E - 140 Avenue de la Physique - St Martin d’Hères. Accès par interphone, appeler le secrétariat

Orateur : Lucie BAILLY (Laboratoire Sols-Solides-Structures-Risques (3SR), Grenoble)

Since the last decades, the development of fundamental knowledge on mechanics and multi-physics phenomena driving biological systems has enabled the outstanding improvement of biomaterials able to mimic the mechanical behaviour of human soft tissues. Vocal-fold tissues are very challenging to replace as they possess specific abilities to endure large reversible deformations and to vibrate up to more than thousand cycles per second. Such unique performances result from complex physical and biomechanical features which remain poorly understood so far. This is mainly ascribed to a lack of knowledge of their unique macro- and microstructures, very difficult to investigate experimentally. The 3D characterization of each constitutive element at the micrometric scale is a current challenge using confocal microscopy (limited depth of field), micro-IRM (limited spatial resolution) or X-ray microtomography in absorption mode (low sensitivity to distinguish fresh biological components owning similar absorptive properties). In this context, recent experimental and theoretical works obtained in collaboration between researchers and clinicians from 3SR laboratory, GIPSA-lab and LADAF will be presented. These works aim (i) at characterizing the 3D microscale arrangement of the vocal-fold tissue on excised anatomical samples by means of X-ray synchrotron phase-contrast microtomography ; (ii) at studying the relationship between 3D microstructure and vocal-fold biomechanical behaviour using a multiscale modeling approach. Regarding the experimental part, a morphological and histological database will be presented, quantifying the 3D geometries, orientations and densities of vocal-fold fibrous structure. Regarding the theoretical part, a micro-mechanical model of the vocal folds will be proposed, accounting for the fibrous networks of the tissue. The impact of several microstructural parameters (fiber-bundles initial diameter, waviness and orientation) on the vibro-mechanical response of the tissue will be discussed.

Contact : catherine.quilliet@univ-grenoble-alpes.fr

Discipline évènement : (Physique)
Entité organisatrice : (LIPhy)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire Mat. Molle/grise)
Site de l'évènement : Domaine Universitaire de St Martin d’Hères

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