The subthalamic nucleus involvement in motivation and emotion
Jeudi 26 septembre 2013 11:30
- Duree : 1 heure
Lieu : Salle des conseils (4ème étage), Grenoble Institut des Neurosciences (GIN) - Bât. Edmond J. Safra, Chemin Fortune Ferrini CHU, La Tronche
Orateur : Christelle Baunez (INT, UMR7289 CNRS, Université Aix-Marseille)
The subthalamic nucleus (STN) is the current target for the treatment of Parkinson’s disease, but its involvement in non-motor processes has been also demonstrated and led to also target it for the treatment of obsessive compulsive disorders. Here, we will review data obtained in the rat showing the effects of STN inactivation, by either lesions or deep brain stimulation (DBS), on motivation for food (sucrose), cocaine, heroin, alcohol and nicotine. Inactivation of the STN does not affect consummatory processes, but seems to act on incentive motivation (responses to cues associated with a given reward). STN inactivation can induce opposite effects on motivation for natural reward or for various drugs of abuse, decreasing motivation for drugs, while increasing motivation for sweet food reward [1,2]. STN inactivation can also prevent the loss of control over drug or alcohol intake. These data support our hypothesis that STN could be an interesting target for te treatment of addiction and DBS could be the appropriate surgical tool. More recent studies have allowed us to reveal that some of these effects could be related to a decreased affect, since emotional responses are decreased after STN lesions.
[1] Baunez C, Dias C, Cador M, Amalric M (2005) The subthalamic nucleus exerts an opposite control on cocaine and natural rewards. Nature Neuroscience 8(4):484-9
[2] Rouaud T*, Lardeux S*, Panayotis N, Paleressompoulle D, Cador M, Baunez C (2010) Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation. P. Natl. Acad. Sci. USA 107:1196-1200
Contact : veronique.coizet@ujf-grenoble.fr
Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (GIN)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire Grenoblois de Neurosciences)
Site de l'évènement : Pôle Santé / La Tronche
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