How cells build up architecture : force transmission and adhesion formation during cell spreading

Orateur : Jonathan FOUCHARD (Laboratoire Matière et Systèmes Complexes, MSC, Université Paris Diderot)

In this experimental work, I address the question of cells mechanical intercation with their substrate that lead them to take their shape. In other words, I wonder how cells adhere to their substrate and how they apply forces on it. We know that these phenomena are somehow controlled by cell shape. To explain this effect, an extensive litterature focused on the molecular actors of the cell-substrate contact (i.e the ligand-integrin bounds) which are at the root of biological signalisation. Here, I will show how the overall cell shape (not only its 2D extension), and particularly the cell contact angle act on both traction force generation and adhesion. Then, I will show how substrate geometry affects cell spreading and adhesion.

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