Redox Biology of HIV-1 Entry : Basic Biology and Applications in Antiviral Ligand Design

Orateur : Dr Alexio CAPOVILLA (Department of Molecular Medicine & Haematology, University of the Witwatersrand Medical School, Johannesburg, South Africa)

Entry of Human Immunodeficiency Virus (HIV) into host cells is initiated by interaction between the viral envelope glycoprotein (gp120) and host receptor CD4. Emerging evidence suggests the importance of cell surface disulphide reductase activity for efficient HIV entry, although the biochemical reasons for this are poorly understood. The presentation will report on recent data generated in our laboratory that provide insights into the significance of such activity on CD4 for HIV replication. The implication of these findings for recognition virus by antibody and the development of novel CD4-directed ligands as candidate antiviral therapies will be discussed.

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