New vaccine approaches for human viral diseases : preclinical studies in NHP
Vendredi 19 octobre 2012 12:10
- Duree : 1 heure
Lieu : Institut Jean Roget, Salle de Conférence du 5ème Etage, Faculté de Médecine-Pharmacie, Domaine de la Merci, La Tronche. Pour y accéder : Prenez l’ascenseur sud.
Orateur : Roger Legrand (CEA, Institute of Emerging Diseases and Innovative Therapies (iMETI), University Paris 11 )
The Division of Immuno-Virology is devising and investigating various innovative approaches based on original viral and non‐viral DNA delivery methods, multivalent recombinant DNA vaccines, new adjuvants, and recombinant commensal bacteria. Our main goal is to decrease the viral load (therapeutic vaccine) as well as blocking virus entry through the mucous membranes (preventative vaccine). By combining skin electroporation and an original multigenic DNA vaccine, we have recently obtained long‐lasting and highly effective systemic SIV‐specific immunity in challenged monkeys. Novel avenues based on the use of dendritic cells are also being explored. We are developing our capability to quantify the expansion, activation and migration of various subsets of immune cells in vivo in infected and/or vaccinated primates to evaluate vaccine candidates further as a prerequisite to human clinical trials and to increase our understanding of critical steps in virus entry and replication. This will be made possible by the quite unique capability of the CEA in imaging technologies at high‐resolution.
Contact : cordelia.bisanz@ujf-grenoble.fr
More information on : http://ijr.ujf-grenoble.fr/seminars_d.php?oid=511
Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (Institut Jean Roget)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire IJR)
Site de l'évènement : Pôle Santé / La Tronche
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