Intestinal metaplasia of the stomach : a model of tissue regeneration with aberrant differentiation

Orateur : Raquel ALMEIDA (Differentiation and Cancer Group, Institute of Molecular Pathology and Immunology University of Porto, Portugal)

Intestinal metaplasia of the stomach is a pre-neoplastic lesion that appears following Helicobacter pylori infection and that confers increased risk for gastric cancer development. It is induced by de novo expression of the intestine-specific transcription factor CDX2 in the gastric mucosa. However, the regulatory mechanisms and molecular pathways involved in the triggering and maintenance of CDX2 expression in the stomach are yet to be fully unravelled. A more comprehensive understanding of how intestinal metaplasia arises and is maintained will be a major breakthrough in the path to therapeutic intervention on the gastric carcinogenic pathway, either aiming at halting its progression or targeting the putative reversion of established lesions. During these past few years, we have contributed to begin uncovering some of the molecular networks involved in the different stages of this carcinogenic process, focusing on understanding CDX2 regulation.

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