Glycosaminoglycan-based Biomaterials for Mesenchymal Stem Cell Differentiation
Mardi 10 juin 2014 14:00
- Duree : 1 heure
Lieu : Salle M253- Grenoble - INP Phelma Minatec 2nd étage
Orateur : Dr. Johnna S. Temenoff
Associate Professor, Coulter Department of Biomedical Engineering
Georgia Institute of Technology/Emory University, Atlanta (USA)
Abstract : Multipotent mesenchymal stem cells (MSCs) have been widely explored as a means to repair or regenerate a variety of tissues, particularly in orthopaedics. However, how these cells respond to cues from their environment, particularly soluble signals, to determine cell fate remains largely unknown. We have recently developed a family of glycosaminoglycan (GAG)-based biomaterials to modulate cellular response to soluble cues. Our results suggest that material sulfation level plays a role in mesenchymal stem cell differentiation into orthopaedic-related phenoytpes, and that this may be exploited in controlled ways to direct differentiation of stem cells both before and after implantation to achieve maximal healing of orthopaedic defects.
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