Ebola virus glycoprotein : entry, shielding and potential roles in pathogenicity
Vendredi 6 juin 2014 11:00
- Duree : 1 heure
Lieu : Salle des séminaires de l’IBS - 6 rue Jules Horowitz - Grenoble
Orateur : Olivier REYNARD (Centre International de Recherche en Infectiologie (CIRI), Lyon)
Ebolavirus (EBOV), Marburgvirus and Cuevavirus form the family Filoviridae, a group of enveloped negative-strand RNA viruses responsible for severe haemorrhagic fevers in humans. A single spike glycoprotein (GP) of Ebola is responsible for cell targeting and virus entry. This protein is known to be a key element in Ebola virus pathogenesis. The high glycosylation content contributes to approximately half of the mass of GP, with O-linked glycans conferring a mucin-like property to the C terminus of the GP1 subunit. Through the screening of monoclonal antibodies we identified that the mucin domain is able to induce the masking of cellular surface proteins even masking itself from recognition by antibodies. Molecular mechanisms of Ebola virus neutralization will be discussed.
Contact : odile.kaikati@ibs.fr
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