Identification of Tau-truncated species : Towards deciphering their role in Alzheimer’s disease
Jeudi 9 octobre 2014 11:30
- Duree : 1 heure
Lieu : Amphithéâtre Serge Kampf, Grenoble Institut des Neurosciences (GIN) - Bât. Edmond J. Safra, Chemin Fortune Ferrini CHU, La Tronche
Orateur : Malika HAMDANE (Université Lille 2)
Tau is a microtubule-associated protein that ensures neuronal shape and function. Besides, Tau is a central player in Alzheimer’s disease (AD) and related Tauopathies where it is found aggregated in degenerating neurons. Among post-translational modifications displayed by pathological Tau, truncation is probably of great interest and deserves to be more studied. A major step forward in the understanding of the role of Tau truncation would be to identify the precise cleavage sites of Tau fragments that are observed in AD brains, especially N-terminus sites that are less characterized than C-terminus ones. In this context, we achieved an optimized proteomics approach and identified a number of new N-terminally truncated-Tau species from human brain. The proteomic data as well as preliminary data from cell-based studies of two N-terminally truncated Tau species will be presented.
Keywords : Tau protein, truncation, post-translational modification, LC-MS/MS, microtubule stabilization.
Contact : yves.goldberg@ujf-grenoble.fr
Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (GIN)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire Grenoblois de Neurosciences)
Site de l'évènement : Pôle Santé / La Tronche
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