Role of ECM physical properties on force distribution and cell internal organization

Orateur : Soutenance de thèse de Kalpana MANDAL (LIPhy)

In their microenvironment, cells exert and sense forces via their own internal contractile machinery. Many studies have shown that this bidirectional biomechanical coupling can affect cell behavior in some of its very fundamental biological processes such as adhesion, migration, division or differentiation. Many tools have been developed in order to analyze these type of interactions. I present a combination of two techniques that enable us to fix cell shape as well as it allows to measure forces that cell exerts on their surroundings , by using TFM and micro-patterning in quantitative manner, to elucidate the mechanism governing the spatial distribution of cell internal tension and organization in response to different external adhesive conditions.

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