Structure and function of G protein-coupled receptors
Vendredi 5 octobre 2012 11:30
- Duree : 1 heure
Lieu : Salle des séminaires de l’IBS, 41 rue Jules Horowitz, 38000 Grenoble
Orateur : Vadim CHEREZOV (The Scripps Research Institute, La Jolla, USA)
G protein-coupled receptors (GPCRs) are critical eukaryotic signal transduction gatekeepers, which represent the largest protein family in the human proteome. GPCR-mediated signaling pathways have been related to numerous human diseases, and GPCRs are the targets of an estimated 40% of all drugs currently on the market. During the past few years, GPCR crystallography has experienced exponential growth. The talk will focus on the recent breakthroughs.
In 2012 structures of all four members of the opioid receptors subfamily
have been solved, providing a comprehensive view of the ligand selectivity within the subfamily. Another highlight of the year is the highest resolution GPCR structure to-date of the adenosine A2A receptor at 1.8 Å, shedding light on the role of sodium ions, lipids and
water in modulating receptor function and stability.
Contact : odile.kaikati@ibs.fr
Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (IBS)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire IBS)
Site de l'évènement : Polygone scientifique
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