Imaging of the role of dopamine in behavioural disorders
Mardi 9 décembre 2014 11:30
- Duree : 1 heure
Lieu : Amphithéâtre Serge Kampf, Grenoble Institut des Neurosciences (GIN) - Bât. Edmond J. Safra, Chemin Fortune Ferrini CHU, La Tronche
Orateur : Antonio STRAFELLA (Dept. Neurology, U. of Toronto, Canada)
We often need to adapt behaviour to changing circumstances - to plan novel actions or inhibit pre-potent ones. These decision making process depends on the accurate representations of reward or losses and the inhibition of impulses. Abnormalities in this process can lead to impulse control disorders. In Parkinson´s disease (PD), the decision of which action to take, and the inhibition of harmful behaviour, can be impaired and further worsened by dopaminergic therapy. The combination of PET and fMRI is revealing the mechanisms of poor impulse control in PD. Here, we show the results of neuroimaging studies conducted in PD patients with and without ICDs providing evidence of significant abnormalities in those prefrontal-striatal areas associated with decision making and reward. Proposed mechanisms include abnormal functioning of mesolimbic structures resulting in dysregulation of dopamine.
References :
Antonelli F, Ko JH, Miyasaki J, Lang AE, Houle S, Valzania F, Ray NJ, Strafella AP. Dopamine-agonists and impulsivity in Parkinson’s disease : Impulsive choices vs. impulsive actions. 2014. Human brain mapping ; 2014 ;35(6):2499-506.
Ray N, Miyasaki JM, Zurowski M, Ko JH, Cho SS, Pellecchia G, Antonelli F, Houle S, Lang AE, Strafella AP. Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson’s patients with medication-induced pathological gambling : A [11C] FLB-457 and PET study. Neurobiol Dis. 2012. 48(3):519-25.
R Cilia, SS Cho, T van Eimeren, G Marotta, C Siri, JH Ko, G Pellecchia, G Pezzoli, A Antonini, AP Strafella. Pathological gambling in patients with Parkinson’s disease is associated with fronto-striatal disconnection : a path modeling analysis. Movement Disord. 2011, 26(2):225-33.
T van Eimeren, G Pellecchia, R Cilia, B Ballanger, TDL Steeves, S Houle, JM Miyasaki, M Zurowski, AE Lang, AP Strafella. Drug-induced deactivation of inhibitory networks predicts pathological gambling in PD. Neurology 2010 ; 75(19):1711-6.
Contact : Paul.Krack@ujf-grenoble.fr
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