The role of microtubule-associated ATPases in zebrafish spinal motor axon navigation
Jeudi 11 décembre 2014 11:30
- Duree : 1 heure
Lieu : Amphithéâtre Serge Kampf, Grenoble Institut des Neurosciences (GIN) - Bât. Edmond J. Safra, Chemin Fortune Ferrini CHU, La Tronche
Orateur : Coralie FASSIER (CNRS-INSERM-UPMC, Paris)
In neuronal circuit assembly, extrinsic signals are integrated into complex changes in growth cone cytoskeleton that underlie axon guidance decisions. Microtubules are known to be essential for axon guidance processes, but all the actors involved in their organisation and dynamics, as well as their precise mode of action are far from being deciphered. Here, we identify the microtubule-associated ATPase Fidgetin-like 1 as a novel key player in spinal motor axon outgrowth and targeting using loss- and gain-of function analysis during zebrafish development. The knockdown and overexpression of Fidgetin-like 1 cause major defects of axon outgrowth, branching and pathfinding, which eventually result in larval mobility deficits. Our study further reveals, that unlike its closely related microtubule-severing enzyme Spastin, Fidgetin-like 1 does not sever microtubules but exerts its control of spinal motor axon navigation by regulating the binding of +TIPs at microtubule plus-ends and thereby modulating growth cone microtubule dynamics.
Contact : annie.andrieux@ujf-grenoble.fr
Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (GIN)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire Grenoblois de Neurosciences)
Site de l'évènement : Pôle Santé / La Tronche
Prévenir un ami par email
Télécharger dans mon agenda