Modeling crawling cell movement
Lundi 19 janvier 2015 14:00
- Duree : 1 heure
Lieu : Conference room - LIPhy - Bât E - 140 Avenue de la Physique - St Martin d’Hères. Accès par interphone, appeler le secrétariat
Orateur : Falko ZIEBERT (Physikalisches Institut, Albert-Ludwigs-Universität Freiburg, Germany)
Understanding physical mechanisms of cell motility and its relation to substrate properties is essential e.g. for morphogenesis or wound healing and the development of effective treatment techniques for cancer or the design of bio-active surfaces. Clearly it would be desirable to have predictive modeling tools for cells moving on substrates, which may be deformable, heterogeneous, patterned etc.
We present an effective computational model, based on the cell’s shape deformation mediated by the actin cytoskeleton, coupled to the dynamics of adhesion site formation and the elastic response of the substrate. We reproduce and analyze key experimental observations, like stick-slip and more complex motion with concomitant shape oscillations. The model also has been investigated for substrates with patterned adhesiveness and inhomogeneous elasticity, questions which are relevant for the design of selective bio-active substrates for e.g. cell sorting, and the understanding of durotaxis. Finally, I briefly discuss a generalization to many cells that allows to model collective cell migration.
Contact : eric.bertin@ujf-grenoble.fr
Prévenir un ami par email
Télécharger dans mon agenda
RSS 2.0 : Tous les evenements