Polymer switches to manipulate lipid membranes and cells
Lundi 26 janvier 2015 11:00
- Duree : 1 heure
Lieu : Conference room - LIPhy - Bât E - 140 Avenue de la Physique - St Martin d’Hères. Accès par interphone, appeler le secrétariat
Orateur : Christophe TRIBET (Pôle de Chimie Biophysique. ENS-UPMC-CNRS UMR 8640 Paris)
Water-soluble amphiphilic copolymers spontaneously form self-assemblies or assemblies with micelles of detergents or lipid membranes, that can be tailored to optimize properties of complex fluids. Applications to biologically relevant systems include controlled activity of proteins (encapsulation, protection), permeabilization of membranes (e.g. biocide agents, or drug cargoes), or triggering cell adhesion. In this context, clean, non toxic, and remote control of hydrophobicity is highly in demand. Exposure to visible light or weak temperature shifts are compatible with a control at spatial and temporal resolutions matching with biological scales. Here we illustrate i) cell-repellent polymer coatings that can present on demand cell-adherent (e.g. RGD) patterns [1], and ii) photopermeabilization by artificial polymers of model giant liposomes and mammalian cell membranes [2]. We evidenced polymer-triggered and light-triggered lipid scrambling, release of encapsulated Dextran, formation of transient channels in black lipid membranes.
[1] F. Dallier, unpublished data, and Stijn F. M. van Dongen, P. Maiuri, E. Marie, C. Tribet and M. Piel, Adv. Mater. 2013, 25(12):1687-91.
[2] S. Sebai, et al., Angewandte Chemie Int Ed., 2012, 51, 2132-2136.
Contact : lionel.bureau@ujf-grenoble.fr
Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (LIPhy)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire Mat. Molle/grise)
Site de l'évènement : Domaine Universitaire de St Martin d’Hères
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