Transcranial magnetic stimulation (TMS) in cognitive neuroscience : shaping effective “connectivity” of brain networks

Orateur : Hartwig SIEBNER (Hvidovre Hospital, University of Copenhagen)

TMS given before or during an experimental task can produce a change in task performance which is often attributed to a selective disruption of neural processing in the cortical area that has been targeted with TMS. In my talk, I will present a set of fMRI studies which assessed the effects of focal repetitive TMS on functional brain connectivity. These studies provided converging evidence that NIBS dynamically tunes the effective connectivity strength of cortico-cortical and cortico-subcortical connections in functional brain networks and hereby, shapes neural processing well beyond the stimulated brain region. Based on these results, I will argue that dynamic network models that consider NIBS effects on large-scale effective connectivity may be more appropriate than a local virtual lesion model to account for the behavioral impact of TMS, including state- and task-specific effects of TMS on a given brain function.

Télécharger dans mon agenda