A new polymeric scaffold for biomimetic applications : synthetic membranes, artificial channels and multivalent ligands for molecular recognition
Jeudi 16 avril 2015 14:00
- Duree : 1 heure
Lieu : LMGP – Phelma Minatec – 3 Parvis Louis Néel - Grenoble
Orateur : Valessa BARBIER (maître de conférences Université Paris-Est de Créteil - Département de Chimie Moléculaire, CNRS-UJF, Grenoble)
In the framework of research projects aimed at designing polymers with biomimetic features, we recently developed a new polymeric scaffold, dubbed OCD, with geminal substituants located on every third carbon along a polymethylene backbone. Biomimetic nano-objets have been designed such as synthetic membranes made by the self-assembly of amphiphilic liquid crystal (LC) PEG-OCD block copolymers. Crown-ethers substituted OCDs have also been developed as potential biological membrane permeabilizers. We recently showed that they form cation-selective pores within bilipidic membranes, and display an anti-tumoral activity. More recently, a new family of glycopolymers have been synthesized by post-modification of an OCD scaffold and their interaction with carbohydrate-binding proteins have been investigated. The use of glycoOCDs to develop glycoaminoglycans mimics and biomimetic surfaces will be discussed.
Contact : Michele.san-martin@grenoble-inp.fr
Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (LMGP)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire LMGP)
Site de l'évènement : Site Minatec
Prévenir un ami par email
Télécharger dans mon agenda