ATTENTION SEMINAIRE REPORTE "sine die" !!! - Basolateral and central amygdala are both required to recruit dorsolateral striatum-dependent cocaine seeking habits

Orateur : David BELIN (University of Cambridge, UK)

In the development of addiction, drug seeking becomes habitual and controlled by drug-associated cues, and the neural locus of control over behaviour shifts from the ventral to the dorsolateral striatum. The neural mechanisms underlying this functional transition from recreational drug use to drug seeking habits are unknown. Here we demonstrate, combining functional disconnection and electrophysiological recordings of the amygdalo-striatal networks in rats trained to seek cocaine, that both the basolateral and the central amygdala are necessary to recruit dorsolateral striatum dopamine-dependent cocaine seeking habits. These data demonstrate that limbic cortical areas not only tune the function of cognitive territories of the striatum but also facilitate the emergence of maladaptive incentive habits.

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