Translational Imaging for Neuroscience Drug Discovery

Orateur : Markus VON KIENLIN (Magnetic Resonance Imaging and Spectroscopy, F. Hoffmann- La Roche, Basel, Switzerland)

One of the biggest bottlenecks in drug development for brain disorders is the lack of reliable and predictive biomarkers during early clinical testing, which in turn leads to a high failure rate in phase III trials. Pharmacological Magnetic Resonance Imaging and Spectroscopy (phMRI/MRS) have the potential to become an early indicator for neural circuitry engagement in phase I/II trials. This seminar will address this topic from a preclinical perspective, i.e., how functional MRI in rodents can elucidate pharmacologically stimulated activity modulation in relevant brain circuits and how multivariate statistical analysis can generate specific “fingerprints” to classify the brain response [cf. A. Bruns et al., NeuroImage (2015)]. Some technical details will be covered in more detail, such as the need for spatial registration or the choice of appropriate anesthetics. This kind of work provides the scientific basis required for the adequate interpretation of phMRI-results in man.

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