Protein transport from NMDA receptors to the nucleus

Orateur : Michael KREUTZ (Leibniz Institut für Neurowissenschaften, Magdeburg)

In my presentation I will discuss how synaptic signals are transduced from postsynaptic sites to the nucleus, how such signals induce long-lasting changes in gene expression and how this gene expession feeds back to synaptic function. The focus will be on protein transport from NMDA-receptors to the nucleus and I will suggest that specific NMDAR signals induce long-distance trafficking of different so called synapse-to-nucleus protein messenger. Finally, I will discuss how macromolecular complexes deriving from the synapse are docked to nuclear target sites and how they might regulate gene expression in neurodegeneration and plasticity.

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