In silico experimental evolution and its potential application for fighting antibiotic resistance

Orateur : Guillaume BESLON (CNRS UMR 5205 – Université de Lyon, INSA Lyon)

Can we study evolution by letting virtual organisms evolve in computers ? That is the claim of In Silico Experimental Evolution (ISEE), a tool that emerged in the last ten years and that proposes a new view on the evolution of microorganisms. In this talk, I will present the concepts of ISEE and the aevol model developed in the beagle team. Then, I will present the main results gathered so far with the model. In the second part of the talk, I will show how such a model can help fighting antibiotic resistance by (i) identifying "evolutionary safe treatment strategies" and (ii) giving physicians and patient a better insight on the evolutionary rules of antibiotic resistance emergence and spreading.

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