Three-dimensional Scaffolds for Cardiovascular Tissue Engineering

Orateur : Didier LETOURNEUR (INSERM U698, Cardiovascular Bioengineering)

One main challenge of tissue engineering is to create an optimal environment for growing therapeutic cells to regenerate damaged tissues. This environment can be reconstituted by using 3D matrices, in which cells can be organized into a tissue-like structure. We have prepared pullulan/dextran porous matrices having controlled pores and porosity that allowed the proliferation and survival of various stem cells. These porous hydrogels have architectural characteristics adapted to the culture in 3D. Further studies have demonstrated the performance of these matrices for tissue regeneration. Examples for heart, skin and bone will be presented. Applications of these scaffolds included the 3D cell culture, the tissue integration/regeneration, and the design of biocompatible materials for cell, drug and gene delivery by chemical functionalization of the polymers and new formulations.

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