Red Blood Cells Emit Microparticles Which Attack Blood Vessels : The Case of Sickle Cell Anemia
Lundi 14 décembre 2015 14:00
- Duree : 1 heure
Lieu : Conference room - LIPhy - Bât E - 140 Avenue de la Physique - St Martin d’Hères. Accès par interphone, appeler le secrétariat
Orateur : Olivier BLANC-BRUDE (ParCC - Paris Cardiovascular Center @ HEGP – INSERM U970)
Abnormal red blood cells (RBCs) persist in blood circulation during certain diseases. They eventually rupture and release their contents, a process called intravascular hemolysis. Do RBCs disappear ? Not exactly... During hemolysis, RBCs release membrane fragments, called microparticles, which are not harmless. Our observations conducted on RBCs of patients with sickle cell anemia, the most common genetic disease in France, show that RBC microparticles carry hemoglobin in a degraded and toxic form : Heme previously contained in hemoglobin ends up associated with microparticle membranes or exposed on their surface. This feature makes microparticles dangerous. The heme-loaded microparticles are deposited in sensitive areas of the vascular network and promote the occurrence of cardiovascular damage. While the understanding of the influence of RBC microparticles begins to emerge, the exact mechanisms of their release in the circulation remain to be explored.
Contact : thomas.podgorski@ujf-grenoble.fr
Discipline évènement : (Physique)
Entité organisatrice : (LIPhy)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire Mat. Molle/grise)
Site de l'évènement : Domaine Universitaire de St Martin d’Hères
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