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Adenomatous Polyposis Coli protein in a cell-free system
Mardi 15 décembre 2015 13:00 - Duree : 1 heureLieu : Amphithéâtre Serge Kampf, Grenoble Institut des Neurosciences (GIN) - Bât. Edmond J. Safra, Chemin Fortune Ferrini CHU, La Tronche
Orateur : Laurence SERRE (Equipe Arnal)
Discovered in the late 80’s for its direct link to colon cancer, Adenomatous Polyposis Coli protein (APC) was first characterized for its role in the Wnt signaling pathway. In this pathway, APC is part of the degradation complex of beta-catenin and prevents the transcription of specific oncogenes. APC is a ubiquitous protein and takes part in essential cellular processes such as cell division or cell migration. Transcriptomic studies have revealed that APC was abundantly expressed in brain. In neurons, for instance, APC is involved in the development of both axon and post-synaptic compartment. These functions are connected to the cytoskeleton interacting properties of APC. This talk will present some recent structure/function results obtained by our team and discuss how they may shed new light on APC’s biological functions. Contact : yves.goldberg@ujf-grenoble.fr
Entité organisatrice : (GIN)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire Grenoblois de Neurosciences)
Site de l'évènement : Pôle Santé / La Tronche
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