Genome-wide outcome of telomere dysfunction
Jeudi 14 janvier 2016 11:30
- Duree : 1 heure
Lieu : Amphithéâtre Serge Kampf, Grenoble Institut des Neurosciences (GIN) - Bât. Edmond J. Safra, Chemin Fortune Ferrini CHU, La Tronche
Orateur : Eric GILSON (Université de Nice)
Telomeres protect chromosome ends from degradation and inappropriate DNA damage response activation through their association with specific factors. Interestingly, the telomeric protective factor TRF2 is able to bind DNA outside telomeric regions, where it regulates the transcription of genes involved in immunity and cellular differentiation. These findings suggest a signalling pathway by which telomeric changes control the ability of TRF2 to regulate transcription genome-wide. This mechanism may represent a pivotal aspect of development, ageing and telomere-mediated diseases.
Contact : Nathalie.Scher@ujf-grenoble.fr
Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (GIN)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire Grenoblois de Neurosciences)
Site de l'évènement : Pôle Santé / La Tronche
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