Signaling from dendrites to nucleus and environmental effects in striatal neurons
Jeudi 21 janvier 2016 11:30
- Duree : 1 heure
Lieu : Amphithéâtre Serge Kampf, Grenoble Institut des Neurosciences (GIN) - Bât. Edmond J. Safra, Chemin Fortune Ferrini CHU, La Tronche
Orateur : Jean-Antoine GIRAULT (Institut du Fer à Moulin, UMR-S839 Inserm & UPMC, Paris)
As a major entry gate of the basal ganglia, the striatum processes information from the cerebral cortex and thalamus to control action selection and motivation. Striatal processing and plasticity are modulated by dopamine-encoded reward prediction errors. Neurons have complex dendritic trees, receiving numerous inputs at various distances from the cell body. Yet we do not know the rules of molecular signal propagation from dendrites to nuclei, a step necessary for long-lasting plasticity.
Combining modelling and live imaging, we identified a general mechanism by which dendritic geometry counterbalances the effect of dendritic distance for diffusion-based signaling to the nucleus. We also discovered a novel interaction between DARPP-32, a signaling hub in striatal neurons, and adducin, a cytoskeletal protein that regulates synaptic stability. Evidence suggests that this interaction is implicated in the effects of novel enriched environment on responsiveness of striatal neurons.
Contact : Nathalie.Scher@ujf-grenoble.fr
Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (GIN)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire Grenoblois de Neurosciences)
Site de l'évènement : Pôle Santé / La Tronche
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