« avril 2020 »
30 31 1 2 3 4 5
6 7 8 9 10 11 12
13 14 15 16 17 18 19
20 21 22 23 24 25 26
27 28 29 30 1 2 3
Tous les évènements de Physique à venir

Tous les évènements de Biologie / Chimie à venir

Tous les évènements à venir

Les évènements relevant de la Physique et de la Biologie / Chimie sont représentés en turquoise

APP proteolysis and Alzheimer’s disease : could other peptides beside Aβ participate in synaptic failure ?

Jeudi 10 mars 2016 11:00 - Duree : 1 heure
Lieu : Amphithéâtre Serge Kampf, Grenoble Institut des Neurosciences (GIN) - Bât. Edmond J. Safra, Chemin Fortune Ferrini CHU, La Tronche

Orateur : Hélène MARIE (IPCM, Sophia Antipolis)

Identifying the pathological mechanisms causing Alzheimer’s disease is a crucial challenge of the 21st century. In 2009, 35.6 million cases were recorded worldwide and by 2050 we expect 1/85 persons living with the disease. No cure or effective palliative therapies are currently available. The cellular and molecular underpinnings of memory loss in Alzheimer’s disease are still unclear preventing the development of adequate therapies. Genetic and pre-clinical evidence led to a major hypothesis centered on the synaptotoxic role of amyloid-beta (Aβ) peptide assemblies within the hippocampus, which originate from amyloid precursor protein (APP) cleavage. Yet, several clinical trials show that removing Aβ aggregates from brain areas controlling memory processes, such as the hippocampus, did not provide the expected protection against cognitive decline. While further pre-clinical and clinical research is underway to explain this disappointing result, the scientific community is also looking for additional culprits implicated in disease etiology. I will present two new studies demonstrating that two other peptides originating from APP cleavage, the C-terminal end of APP called AICD and a newly discovered peptide called Aη, could also impact hippocampal synaptic function. Our findings shed further light on the biological relevance of APP processing in physiological and pathological conditions. Our work is also of high pre-clinical relevance regarding ongoing APP-processing related therapeutic strategies (e.g. BACE1 inhibitors).

Contact : fabien.lante@univ-grenoble-alpes.fr

Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (GIN)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire Grenoblois de Neurosciences)
Site de l'évènement : Pôle Santé / La Tronche

Prévenir un ami par email

Télécharger dans mon agenda

Cafés sciences de Grenoble | UdPPC de Grenoble | Sauvons Le Climat | Cafe des sciences de Vizille
Accueil du site | Secretariat | Espace privé | Suivre la vie du site RSS 2.0 : Tous les evenements Suivre la vie du site RSS 2.0 : Evenements de Physique Suivre la vie du site RSS 2.0 : Evenements de Biologie & Chimie