A New Polymeric Scaffold for Biomimetic Applications
Lundi 14 mars 2016 14:00
- Duree : 1 heure
Lieu : Conference room - LIPhy - Bât E - 140 Avenue de la Physique - St Martin d’Hères. Accès par interphone, appeler le secrétariat
Orateur : Valessa BARBIER (Université Paris-Est de Créteil)
In the framework of research projects aimed at designing polymers with biomimetic features, we have developed a new polymeric scaffold, dubbed OCD for Oligomers from Cyclopropane Dicarboxylates monomers. They have geminal substituants located on every third carbon along a polymethylene backbone and are obtained by Anionic Ring Opening Polymerization using a phosphazene base to generate in situ the polymerisation initiator.
Biomimetic nano-objets have been designed such as synthetic membranes made by the self-assembly of amphiphilic liquid crystal (LC) PEG-OCD block copolymers. Crown-ethers substituted OCDs have also been developed as potential biological membrane permeabilizers. Cation-selective pores within model bilipidic membranes, as well as an anti-proliferative effect towards cancer cells have been observed. More recently, a new family of glycopolymers have been synthesized by post-modification of an OCD scaffold using the thiol-ene radical addition and their interactions with carbohydrate-binding proteins have been investigated.
To conclude, the use of OCDs to design biomimetic surfaces will be discussed.
Contact : delphine.debarre@univ-grenoble-alpes.fr
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