Cannabinoid-induced actomyosin contraction shapes neuronal structure and connectivity at multiple spatiotemporal scales
Jeudi 19 mai 2016 11:30
- Duree : 1 heure
Lieu : Amphithéâtre Serge Kampf, Grenoble Institut des Neurosciences (GIN) - Bât. Edmond J. Safra, Chemin Fortune Ferrini CHU, La Tronche
Orateur : Zsolt LENKEI (ESPCI ParisTech)
My group worked during the last decade on the mechanism and cell physiological significance of tonic endocannabinoid signaling and its effect on CB1 receptors. After a brief review of this work, I will present new, partly yet unpublished and unexpected findings about the role of presynaptic actomyosin contraction in neuronal structure and synaptic plasticity. Finally, I will show the interdisciplinary development of new tools to investigate the role of cannabinoid-induced actomyosin contraction in brain structure and connectivity.
Relevant recent publications :
Renard et al. Eur Neuropsychopharmacol. 2015
Chatelin et al. Journal of Cerebral Blood Flow and Metabolism, 2015
Errico et al. Nature, 2015
Ladarre et al. Frontiers in Cellular Neuroscience, 2015
Roland et al. eLife, 2014
Osmanski et al. Nature Communications, 2014
Simon et al. J Mol Cell Biol. 2013
Thibault et al. Cerebral Cortex. 2013
Contact : Frédéric.Saudou@univ-grenoble-alpes.fr
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