ATTENTION !!! Séminaire annulé et reporté au 06/09 - Microtechnologies for skeletal muscle tissue engineering
Mardi 28 juin 2016 14:00
- Duree : 1 heure
Lieu : Grenoble INP-Phelma, Laboratoire LMGP-2ème étage-salle de séminaire, 3 parvis Louis Néel - 38000 Grenoble
Orateur : Benoît KALMAN (Phd Student - IMBM)
Actual in vitro models for skeletal muscle tissue engineering present many limitations for high-content screening analysis. Two-dimensional (2D) models do not mimic the native cellular microenvironment (Monge et al. 2012), whereas 3D models require large amounts of cells, thus limiting the reproducibilityof experiments (Chiron et al. 2012 ; Madden et al. 2015).
In our lab we developed two innovative technics based on microtechnologies to study skeletal muscle tissue. The first one consist in a PDMS platform structured by microgrooves that allows to align tridimensional myotubes and study myogenesis. The second one is a microfabricated platform that enables the generation of arrays of 3D microtissues and give direct access to skeletal muscle contractility.
Here we will introduce those tools and show how we succeeded in generating and studying 3D aligned human myotubes and 3D microtissues from human myoblast.
Contact : Michele.san-martin@grenoble-inp.fr
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