Fluidization and Active Thinning by Molecular Kinetics in Active Gels
Lundi 20 février 2017 14:00
- Duree : 1 heure
Lieu : Conference room - LIPhy - Bât E - 140 Avenue de la Physique - St Martin d’Hères. Accès par interphone, appeler le secrétariat
Orateur : Ricard ALERT (Departament de Fisica de la Materia Condensada, Facultat de Fisica, Universitat de Barcelona, Spain)
We derive the constitutive equations of an active polar gel from a model for the stochastic dynamics of elastic molecules that link polar elements. Molecular binding kinetics induces the fluidization of the material, giving rise to Maxwell viscoelasticity and, provided that detailed balance is broken, to the generation of active stresses. We give explicit expressions for the transport coefficients of active gels in terms of molecular properties, including nonlinear contributions on the departure from equilibrium. In particular, when activity favors linker unbinding, we predict a decrease of viscosity with activity – active thinning – of kinetic origin, which could explain some experimental results on the cell cortex. By bridging the molecular and hydrodynamic scales, our results could help understand the interplay between molecular perturbations and the mechanics of cells and tissues.
Contact : daniel-alejandro.matoz-fernandez@univ-grenoble-alpes.fr ou kirsten.martens@univ-grenoble-alpes.fr
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