Fas non apoptotic signaling pathways and their role in inflammation

Orateur : Patrick LEGEMBRE (Centre Eugène Marquis, Rennes)

CD95 (also known as Fas) is considered as a death receptor and it belongs to the TNF (tumor necrosis factor) receptor family. Its ligand, CD95L is a transmembrane cytokine (m-CD95L) that can be cleaved by metalloproteases to release a soluble ligand (cl-CD95L). While m-CD95L, present at the surface of activated immune cells, orchestrates the elimination of transformed/infected cells and the immune contraction, cl-CD95L behaves as a protooncogene enhancing inflammation in lupus and the risk of metastatic occurrence in breast cancers. This lecture will present i) how CD95 switches from implementing cell death to nonapoptotic signaling pathways and ii) what are the cells whose function is deregulated by the naturally-processed ligand both in breast cancers and lupus patients. In conclusion, our work revisited the role of this receptor, and showed that beyond its apoptotic function, this couple is a main actor of inflammation.

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