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Aquaporin water channels and their roles in brain physiology and pathophysiology

Mercredi 5 juillet 2017 11:00 - Duree : 1 heure
Lieu : Amphi – Institut des Sciences Cognitives Marc Jeannerod, Hopitaux Est, 67 blvd Pinel 69500 Bron

Orateur : Ole Petter OTTERSEN (MD, PhD - Rector, University of Oslo, Norway; President-elect Karolinska Institutet, Stockholm, Sweden)

You are cordially invited to meet Prof. OTTERSEN during the complementary Luncheon Buffet following the seminar Registration required : https://beta.doodle.com/poll/d9avukkm8uradmk8#table

Ole Petter OTTERSEN has made seminal discoveries in the field of water transport in the brain and other tissues through unique channels called “Aquaporins”, as Professor of Medicine at the University of Oslo. He achieved this through the development and application of novel technological approaches, and correlating them with physiological and clinical observations. Further, he and his collaborators have contributed to our understanding of the structure, biology and therapeutic potential of regulating their action. Aquaporin-4 (AQP4) is one of the most abundant molecules in the brain and is particularly prevalent in astrocytic membranes at the blood-brain and brain-liquor interfaces. Prof. OTTERSEN will offer a brief general overview of the topic and share some exciting soon-to-be-published work on the central role of AQP4 in the “glymphatic” waste clearance system that is dependent on glia and akin to the lymphatic system in other organs. He has directed The Center of Excellence In Molecular Biology & Neuroscience and coordinated one of the first Nordic Centers of Excellence in Molecular Medicine, before being elected Rector of the University of Oslo. In August 2017 he will become President of the Karolinska Institutet in Stockholm. Prof. OTTERSEN is chair of the Kavili prize committee in Neuroscience. He has received several awards including the Anders Jahre Medical Prize and Lundbeck’s Nordic Research Prize and a Doctorat Honoris Causa from the ENS Lyon.

Selected References

Nielsen S, Nagelhus EA, Amiry-Moghaddam M, Bourque C, Agre P, Ottersen OP (1997). Specialized membrane domains for water transport in glial cells : high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J Neurosci 17:171-80. PMID : 8987746.

Amiry-Moghaddam M, Williamson A, Palomba M, Eid T, de Lanerolle NC, Nagelhus EA, Adams ME, Froehner SC, Agre P, Ottersen OP. (2003). Delayed K+ clearance associated with aquaporin-4 mislocalization : phenotypic defects in brains of alpha-syntrophin-null mice. Proc Natl Acad Sci USA 100:13615-20. PMID : 14597704 ;

Nagelhus EA, Ottersen OP. (2013). Physiological roles of aquaporin-4 in brain. Physiological Reviews 93:1543-62. doi : 10.1152/physrev.00011.2013. PMID : 24137016 ; PMCID : PMC3858210.

Enger R, Dukefoss DB, Tang W, Pettersen KH, Bjørnstad DM, Helm PJ, Jensen V, Sprengel R, Vervaeke K, Ottersen OP, Nagelhus EA. (2017). Deletion of Aquaporin-4 Curtails Extracellular Glutamate Elevation in Cortical Spreading Depression in Awake Mice. Cereb Cortex. 27:24-33. doi : 10.1093/cercor/bhw359. PMID : 28365776.

Contact : pascale.michelon@univ-lyon2.fr

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