A new mechanism for development of autoimmune disease and B cell lymphomas
Mardi 19 septembre 2017 11:00
- Duree : 1 heure
Lieu : Salle de Conférence de l’IAB - Rond Point de La Chantourne, 38700 La Tronche (arrêt de tram Grand Sablon, ligne B)
Orateur : Bjarne BOGEN (University of Oslo, Norway)
A recent “tour de force” paper (Khodadoust et al., Nature, 543:723, 2017) sought to define neoan%gens presented by MHC molecules in pa+ents with mantle cell lymphoma. The authors conclude : “Remarkably, all discovered neoan8genic pep8des were exclusively derived from the immunoglobulin heavy or light chain variable region”. This conclusion strongly supports the concept of idiotype (Id) driven T-B collabora&on and its ability to cause B cell diseases (autoimmune diseases and B cell lymphomas). The concept of Id-driven T-B collabora’on was first proposed in 1993 and has since been demonstrated to cause autoimmune disease and B lymphomas in mice. The basics of Id-driven T-B collabora)on will be explained. A novel and more physiologic mouse model for chronic Id-driven T-B collabora’on will be presented. In this model, mice develop autoimmunity followed by later development of diffuse large cell B lymphomas with germinal center characteris3cs. Most likely, chronic Id-driven T-B collabora)on causes relentless B cell prolifera,on, accumula,on of muta(ons, and finally malignant transforma(on. The findings suggest new therapeu1c
strategies in B cell lymphoma.
Contact : karin.sadoul@univ-grenoble-alpes.fr
Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (IAB)
Nature évènement : (Séminaire)
Evènement répétitif : (Conférence du GIRC)
Site de l'évènement : Pôle Santé / La Tronche
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