Drug targeting to tumors : Concepts and barriers vs. ever more nanocarriers

Orateur : Twan LAMMERS (RWTH University, Aachen, Germany)

Nanomedicines are 1-100(0) nm-sized carrier materials designed to improve the biodistribu)on and the target site accumula-on of systemically administered (chemo-) therapeutic drugs. By delivering drug molecules more efficiently to pathological sites, and by preventing them from accumulating in healthy issues, nanomedicines are able to improve the balance between efficacy and toxicity. Nanomedicines primarily rely on the Enhanced Permeability and Retention (EPR) effect for efficient target site accumulation, which is notoriously known to be highly variable, both in animal models and in patients. To overcome this high heterogeneity in nanomedicine-based tumor targeting, and to improve the (pre-) clinical performance of tumor-targeted nanomedicine products, we are working on setups and strategies to modulate, combine, avoid and image EPR. In the present lecture, several of these strategies will be highlighted, including pharmacological and physical modulation of tumor blood vessels and the microenvironment, and theranostic concepts for pre-selecting patients for (more) individualized and improved nanomedicine therapies.

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