Towards Virtual Platelet

Orateur : Anastasia SVESHNIKOVA (Lomonosov Moscow State University, Russia)

Despite being small and anuclear, platelets possess numerous receptors and complex signaling machinery in order to make life-or-death decisions during hemostasis. They are capable of a number of functional responses beginning from shape change and integrin alphaIIbbeta3 activation and ending with microvesicle release and contraction. Our team combines computational systems biology methods with experiments in order to get insight into how platelets work, with the ultimate goal to build (together with our collaborators, as this ambitious project requires a lot of international effort) a complete computer model capturing major aspects of platelet functioning, a Virtual Platelet. Here I will present our recent data dealing with interaction of platelet G-protein-dependent signaling pathways (P2Y12 and PAR1, PAR1 and PAR4) and subsequent regulation of functional responses (first of all, integrin alphaIIbbeta3 activation).

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