Hydrodynamic Instabilities, Waves and Turbulence in Spreading Epithelia
Lundi 27 novembre 2017 14:00
- Duree : 1 heure
Lieu : Conference room - LIPhy - Bât E - 140 Avenue de la Physique - St Martin d’Hères. Accès par interphone, appeler le secrétariat
Orateur : Carles BLANCH-MERCADER (University of Geneva, Departement of Biochemistry, Switzerland)
In the last decades a great deal of attention has been focused on spreading epithelial monolayers, as a model system to study morphogenesis, tissue repairing or cancer invasion. These cellular systems exhibit a rich repertoire of dynamical states. For example, propagation of elastic mechanical waves at time scales of several hours, where one would expect a fluid-like behaviour [1]. In our study, we show that some observations can be conciliated through a minimal hydrodynamical description of a compressible active polar fluid by introducing two sources of activity : traction forces with the environment and intercellular contractile stresses. The physical model harbours a new periodic oscillatory instability controlled by cell-substrate interactions. Near criticality, the system admits a reduced description in the terms of the Complex Ginzburg-Landau equation that we compute analytically [2]. Thus, we report a full characterisation of all dynamical states and found that they are comprised between coherent nonlinear waves to turbulent states. In the last part of the seminar, I will discuss these results in the light of recent experimental findings from P. Silberzan group on collective migration of weakly-adherent epithelial cells [3].
[1] C. Blanch-Mercader, R. Vincent, E. Bazellières, X. Serra-Picamal, X. Trepat, and J. Casademunt, Soft matter, (2017).
[2] C. Blanch-Mercader and J. Casademunt, Soft matter (2017).
[3] C. Blanch-Mercader *, V. Yashunsky *, S. Garcia, G. Duclos, L. Giomi, and P. Silberzan. arXiv (2017).
Contact : pierre.recho@univ-grenoble-alpes.fr
Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (LIPhy)
Nature évènement : (Séminaire)
Evènement répétitif : (Séminaire Mat. Molle/grise)
Site de l'évènement : Domaine Universitaire de St Martin d’Hères
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