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Nanoscintillators-induced photodynamic therapy : towards overcoming the low penetration depth of light in tissue

Mardi 20 mars 2018 11:00 - Duree : 1 heure
Lieu : CEA, Bâtiment C5, Salle 421A - 17 rue des martyrs - 38000 Grenoble

Orateur : Anne-Laure BULIN (Rayonnement Synchrotron et Recherche Médicale, ESRF)

Photodynamic therapy (PDT) is a cancer therapy that demonstrates promising results for the treatment of several cancer types that have dismal prognoses, including brain, gastrointestinal and ovarian cancers. The PDT efficacy stems from non-toxic molecules (photosensitizers) that generate reactive oxygen species in tumor tissues upon light irradiation, inducing cytotoxicity. Although promising, PDT is limited by the shallow penetration of light in tissue and its application remains restricted to small and/or superficial tumors. Recently, technological advances on nanoscintillators have opened the door towards deep tissue PDT. Nanoscintillators are down-converting nanoparticles that absorb high energy X-ray photons and emit visible light, that can subsequently excite nearby photosensitizers and induce PDT in deep tissue embedded tumors and throughout large tumor volumes. Through this mechanism, the RT/PDT combination treatment benefits from three therapeutic components : (1) the RT, (2) the PDT and (3) the radiation dose enhancement effect caused by the accumulation of nanoscintillators with high-Z elements in the tumor tissue. Since the introduction of this idea, proofs of concept have been reported, yet many questions remain to be answered.

In this presentation, I will discuss the relevance of inducing PDT during RT using nanoscintillators and describe preliminary data that demonstrate the potential of this promising cancer treatment at the interface of physics and biology.

Contact : Jean-Luc Ravanat

Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (INAC/SyMMES)
Nature évènement : (Séminaire)
Site de l'évènement : Site CEA avec accès badge

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