Chemical and mechanical cues controls collective cell migration
Vendredi 18 mai 2018 10:30
- Duree : 1 heure
Lieu : Salle de Conférence de l’IAB - Rond Point de La Chantourne, 38700 La Tronche (arrêt de tram Grand Sablon, ligne B)
Orateur : Roberto MAYOR (University College London, England)
Collective cell migration is essential for morphogenesis, tissue remodelling, and cancer invasion. In vivo, groups of cells move in an orchestrated way through tissues. This movement requires forces and involves mechanical as well as molecular interactions between cells and their environment. Here I will describe the role and interplay that mechanical and chemical signals play on collective cell migration of neural crest cells, an embryonic cell population whose migratory behaviour has been likened to cancer invasion. I will describe how neural crest cells can respond more efficiently to chemoattractants when they are part of a group than as single cells and the role of connexin in this collective cell response. In addition, I will describe how an increase in mechanical stiffens of surrounding tissues can trigger collective cell migration. Our results raise the exciting idea that tissue mechanics combines wtih molecular effectors to coordinate morphogenesis.
Contact : karin.sadoul@univ-grenoble-alpes.fr
Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (IAB)
Nature évènement : (Séminaire)
Site de l'évènement : Pôle Santé / La Tronche
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