Mechanisms of nanoparticle interactions with lipid membranes
Mardi 29 mai 2018 11:00
- Duree : 1 heure
Lieu : Salle de Conférence de l’IAB - Rond Point de La Chantourne, 38700 La Tronche (arrêt de tram Grand Sablon, ligne B)
Orateur : Vladimir A. BAULIN (Université Rovira i Virgili, Tarragone, Espagne)
Design of nanomaterials able to cross lipid bilayers is a challenging task in nanotechnology. Large variety of shapes, sizes and surface coatings are used for the design of nanomaterials to overcome this barrier. However, the potential barrier is quite high for carbon nanotubes and nanoparticles to cross the lipid bilayer to translocate by thermal motion. It is generally accepted that small hydrophobic nanoparticles are blocked by lipid bilayers and accumulate in the bilayer core, while nanoparticles with sizes larger than 5 nm can only penetrate cells through a slow energy-dependent processes such as endocytosis, lasting minutes. In one example, we show how variation of hydrophobicity of the nanoparticles can lead to passive translocation of nanoparticles through lipid bilayer. This adsorption transition through reversible destabilization of the structure of the bilayer induces enhanced permeability for water and small solutes. In another example, we demonstrate that lipid-covered hydrophobic nanoparticles may translocate through lipid membranes by direct penetration within milliseconds.
Contact : karin.sadoul@univ-grenoble-alpes.fr
Discipline évènement : (Biologie / Chimie)
Entité organisatrice : (IAB)
Nature évènement : (Séminaire)
Evènement répétitif : (Mardis de l’IAB)
Site de l'évènement : Polygone scientifique
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